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Berberine – a natural alternative to metformin

Comparison

  • Both berberine and metformin have been studied and used for longevity.
  • Berberine is an alternative to metformin and is reported to be just as effective in treating diabetes and controlling blood sugar levels.
  • Berberine increases glucose consumption by inhibiting complex 1 of the electron transport chain, which is part of mitochondrial respiration.
  • While both compounds lower cholesterol, berberine has the added benefit of limiting inflammation by activating pro-inflammatory enzymes L-Kappa B Kinase and Rho GTP-ASE.
  • Metformin has good bioavailability and is well absorbed by the body, while berberine’s absorption is not as efficient, with a significant portion being metabolized by the liver.
  • There have been studies suggesting that berberine, when used in conjunction with exercise, may provide greater improvement in triglycerides, LDL, LHL, CRP levels, and exercise performance compared to metformin.

It is important to note that further research is needed to fully understand the potential benefits and limitations of both berberine and metformin. It is always recommended to consult with a healthcare professional before making any changes to medication or treatment plans.

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